8.A.133.1.13
E3 ubiquitin-protein ligase, TRIM7, that have both tumor-promoting and
tumor-suppressing activities and functions in several biological
processes including innate immunity, regulation of ferroptosis as well
as cell proliferation and migration (Fan et al. 2021). It also acts
as an antiviral effector against multiple viruses by targeting specific
viral proteins for ubiquitination and degradation including norovirus
NTPase protein or SARS-CoV-2 NSP5 and NSP8 proteins (Liang et al. 2022). TRIM7 suppresses the tumorigenesis of gastric cancer by targeting the SLC7A11 cystine/glutamate amino acid transporter (Chen et al. 2024). Targeting Zfp36 (mRNA decay activator protein) combats cardiac hypertrophy and provides insight into ferroptosis pathways (Zhang et al. 2025).
|
| Accession Number: | Q9C039 |
|---|
| Protein Name: | Tripartite motif-containing protein 3 |
|---|
| Length: | 744 |
|---|
| Molecular Weight: | 80830.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
|---|
| Substrate |
protein |
|---|
1: MAKREDSPGP EVQPMDKQFL VCSICLDRYQ CPKVLPCLHT FCERCLQNYI PAQSLTLSCP
61: VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE DPHPLSVVAG RPLSCPNHEG
121: KTMEFYCEAC ETAMCGECRA GEHREHGTVL LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI
181: ALVGGISQQL QERKAEALAQ ISAAFEDLEQ ALQQRKQALV SDLETICGAK QKVLQSQLDT
241: LRQGQEHIGS SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL
301: EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK DGRLVRTGSA
361: ELRAEITGPD GTRLPVPVVD HKNGTYELVY TARTEGELLL SVLLYGQPVR GSPFRVRALR
421: PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV RRPSSMYSTG GKRKDNPIED ELVFRVGSRG
481: REKGEFTNLQ GVSAASSGRI VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA
541: VDTNGDIIVA DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF
601: TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS ADGEFLFKFG
661: SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG SFLSYINTSA EPLYGPQGLA
721: LTSDGHVVVA DAGNHCFKAY RYLQ