| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.160.1.1 | p120 catenin (catenin δ-1) (CTND1; CTNND1) of 968 aas and 0 TMSs. During internalization and trafficking, human papillomavirus (HPV) moves from the cell surface to the endosome where the transmembrane protease, gamma-secretase, promotes insertion of the viral L2 capsid protein into the endosome membrane (Harwood et al. 2020). | Eukaryota |
Metazoa, Chordata | p120 catenin (catenin δ1) of Homo sapiens |
|
8.A.160.1.2 | Uncharacterized protein of 1086 aas. | Eukaryota |
Euglenozoa | UP of Trypanosoma cruzi |
|
8.A.160.1.3 | ARM REPEAT PROTEIN INTERACTING WITH ABF2, ARIA, of 710 aas. At may act as a substrate-specific adapter of an E3
ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins. It acts as a positive regulator of the ABA response via the
modulation of the transcriptional activity of ABF2, a transcription
factor which controls ABA-dependent gene expression via the G-box-type
ABA-responsive elements. It is a negative regulator of seed germination and
young seedling growth (Kim et al. 2004). | Eukaryota |
Viridiplantae, Streptophyta | ARIA of Arabidopsis thaliana (Mouse-ear cress) |
|
8.A.160.1.4 | Kelch-like protein receptor of 500 aas and possibly 6 or more C-terminal TMSs. It is a component of a cullin-RING-based BCR
(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the
ubiquitination of target proteins, such as NPTXR, leading most often to
their proteasomal degradation (Jiang et al. 2005). It may be a subunit of AMPA receptors (Matthews et al. 2021). | Eukaryota |
Metazoa, Chordata | KLHL2 of Homo sapiens |
|
8.A.160.1.5 | Kelch-like protein 3, KLHL3, of 587 aas and 0-2 N-terminal TMSs. Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (Furukawa et al. 2003, Wu and Peng 2013). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (Ohta et al. 2013, Wu and Peng 2013). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney. It is involved in chloride-sensitive signaling that turns the potassium switch on (Hoorn and de Baaij 2022). | Eukaryota |
Metazoa, Chordata | KLHL3 of Homo sapiens |
|
8.A.160.2.1 | Catenin beta-1, Ctnnb1, of 781 aas and 0 TMSs. It is a key downstream component of the canonical Wnt signaling pathway (Akiyama et al. 2004). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome.It is also involved in the regulation of cell adhesion as a component of an E-cadherin:catenin adhesion complex (Yamada et al. 2005; Abe and Takeichi 2008). | Eukaryota |
Metazoa, Chordata | Ctnnb1 of Mus musculus |