8.A.160.2.1
Catenin beta-1, Ctnnb1, of 781 aas and 0 TMSs. It is a key downstream component of the canonical Wnt signaling pathway (Akiyama et al. 2004).
In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1
and GSK3B that promotes phosphorylation on N-terminal Ser and Thr
residues and ubiquitination of CTNNB1 via BTRC and its subsequent
degradation by the proteasome.It is also involved in the regulation of cell adhesion as a component of an E-cadherin:catenin adhesion complex (Yamada et al. 2005; Abe and Takeichi 2008).
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| Accession Number: | Q02248 |
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| Protein Name: | Catenin beta-1 |
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| Length: | 781 |
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| Molecular Weight: | 85471.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS
61: QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT
121: NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK
181: KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL
241: VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC
301: LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA
361: GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA
421: AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM
481: AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL
541: VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV
601: QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF
661: RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEALGYR QDDPSYRSFH
721: SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD
781: L