TCDB is operated by the Saier Lab Bioinformatics Group

8.A.186.  The Stereocilin, STRC, Protein (STRC) Family

STRC is essential to the formation of horizontal top connectors between outer hair cell stereocilia. It is an auditory receptor for cell stereocilium organization, is involved in cell to matrix adhesion as well as detection of mechanical stimuli for sensory perception of sound. AQP1 and STRC, and potentially TMEM255B, are serous (cystic) neoplasm (SCN) markers (Watase et al. 2021).


References associated with 8.A.186 family:

Čada, Z., D. Šafka Brožková, Z. Balatková, P. Plevová, D. Rašková, J. Laštůvková, R. Černý, V. Bandúrová, V. Koucký, S. Hrubá, M. Komarc, J. Jenčík, S. Poisson Marková, J. Plzák, J. Kluh, and P. Seeman. (2019). Moderate sensorineural hearing loss is typical for DFNB16 caused by various types of mutations affecting the STRC gene. Eur Arch Otorhinolaryngol 276: 3353-3358. 31552524
Watase, C., M. Fuse, Y. Ino, C. Naito, and N. Hiraoka. (2021). Novel insights into immunohistochemical analysis for diagnosing serous neoplasm of the pancreas: aquaporin 1, stereocilin, and transmembrane protein 255B. Histopathology 79: 872-879. 34288030