8.A.216. The Golgi SNAP Receptor Complex, Member 1 (GOSR1) Family
The proteins of this family are involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. GS28 belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors. It may play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). It also participates in docking and fusion stages of ER to cis-Golgi transport. It plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.