TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.96.1.1









Mitochondrial TMEM70 with 260 aas and 2 (or 3) TMSs.  Involved in F-type ATPase biogenesis in higher eukaryotes (Houstek et al. 2009). TMEM70 downregulation downregulated the mitochondrial ATPase, ATPB, but upregulated glycolysis-related glucose transporter member 1 (GLUT1) and glucose-6-phosphate dehydrogenase, suggesting a metabolic shift from oxidative phosphorylation to glycolysis, known as the Warburg effect (Mizukami et al. 2017).

Eukaryota
Metazoa, Chordata
TMEM70 in Homo sapiens
8.A.96.1.2









TMEM70 homologue of 240 aas and 2 TMSs.

Eukaryota
Metazoa, Arthropoda
TMEM70 of Anopheles gambiae (African malaria mosquito)
8.A.96.1.3









TMEM70 of 248 aas and 2 TMSs.

Eukaryota
Metazoa, Platyhelminthes
TMEM70 of Clonorchis sinensis (Chinese liver fluke)
8.A.96.1.4









TMEM70 homologue of 148 aas and 2 TMSs.

Eukaryota
Metazoa, Echinodermata
TMEM70 of Strongylocentrotus purpuratus (Purple sea urchin)
8.A.96.1.5









TMEM70 homologue of 260 aas and 2 TMSs.

Eukaryota
Viridiplantae, Streptophyta
TMEM70 of Oryza sativa (Rice)
8.A.96.1.6









TMEM70 homologue of 214 aas and 2 TMSs.

Eukaryota
Metazoa, Nematoda
TMEM70 of Necator americanus (Human hookworm)
8.A.96.1.7









TMEM70 homologue of 256 aas and 2 TMSs.

Eukaryota
Metazoa, Chordata
TMEM70 homologue of Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
8.A.96.1.8









TMEM70 homologue of 286 aas and 2 TMSs.

Eukaryota
Discosea
TMEM70 of Acanthamoeba castellanii
8.A.96.2.1









TMEM70 homologue of 130 aas and 2 TMSs.

Bacteria
Actinomycetota
TMEM70 of Streptomyces scabiei
8.A.96.2.2









TMEM70 homologue of 74 aas and 2 TMSs.

Bacteria
Actinomycetota
TMEM70 of Nocardiopsis dassonvillei (Actinomadura dassonvillei)
8.A.96.2.3









TMEM70 homologue of 68 aas and 2 TMSs.

Bacteria
Actinomycetota
TMEM70 homologue of Thermomonospora curvata
8.A.96.3.1









DUF1499 domain-containing protein of 310 aas and 3 TMSs.

Bacteria
Pseudomonadota
DUF1499 protein of Agrobacterium radiobacter
8.A.96.3.2









Uncharacterized protein of 282 aas and 3 TMSs.

Bacteria
Pseudomonadota
UP of Brucella abortus