| TCID | Name | Domain | Kingdom/Phylum | Protein(s) | ||
|---|---|---|---|---|---|---|
|
8.B.6.1.1 | Ω-agatoxin IVA | Eukaryota |
Metazoa, Arthropoda | Ω-agatoxin IVA of Agelenopsis aperta (P30288) | ||
|
8.B.6.1.2 | Mu-agatoxin II (37aas) | Eukaryota |
Metazoa, Arthropoda | Mu-agatoxin II of Agelenopsis aperta (P11058) | ||
|
8.B.6.1.3 | Mu-agatoxin-Hc1a (Curtatoxin-1) (36aas) | Eukaryota |
Metazoa, Arthropoda | Curtatoxin-1 of Hololena curta (P15967) | ||
|
8.B.6.1.4 | U10-Ctenitoxin-Co1a of 37 aas (Trachsel et al. 2012). | Eukaryota |
Metazoa, Arthropoda | Ctentitoxin of Ctenus ornatus (Oligoctenus ornatus; brazilian spider)
| ||
|
8.B.6.1.5 | Putative toxin of 148 aas | Eukaryota |
Metazoa, Arthropoda | Putative toxin of Tribolium castaneum (red flour beetle) | ||
|
8.B.6.1.6 | U3-Agatoxin Ao1h of 69 aas | Eukaryota |
Metazoa, Arthropoda | Agatoxin of Agelena orientalis | ||
|
8.B.6.1.7 | U2-agatoxin Ao1k of 69 aas. Insect active toxin causing rapid but reversible paralysis in crickets. No activity shown in mammals. Does not show effect on mammalian voltage-gated calcium channels. | Eukaryota |
Metazoa, Arthropoda | Agatoxin of Agelena orientalis | ||
|
8.B.6.1.8 | Tachystatin-B1 of 42 aas. Exhibits stronger antimicrobial activity against Gram-positive bacteria (S. aureus (IC50 is 7.4 µg/ml)), fungi (C. albicans (IC50 is 3.0 µg/ml) and P. pastoris (IC50 is 0.1 µg/ml)) than Gram-negative bacteria (E.coli, no inhibition at 100 µg/ml). Binds to chitin. Does not cause hemolysis on sheep erythrocytes. Has no blocking activity on the P-type calcium channel. | Eukaryota |
Metazoa, Arthropoda | Tachystatin of Tachypleus tridentatus (Japanese horseshoe crab) | ||
|
8.B.6.1.9 | Delta (δ)-amaurobitoxin-Pl1b of 27 aas and 0 TMSs. Insecticidal toxin. Lethal to lepidopteran larvae. No adverse affect is observed when intracerebroventricularly injected in mice at a dose of 0.2 μg but causes reversible paralysis of legs when injected intracerebroventricularly in mice at a dose of 2.0 μg. Binds to site 4 of insect voltage-gated sodium channel (Nav) and inhibits channel inactivation (Corzo et al. 2000; Corzo et al. 2005). | Eukaryota |
Metazoa, Arthropoda | Amaurobitoxin of Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus) | ||
|
8.B.6.2.1 | Delta atracotoxin-Hv1a (Versutoxin) (42aas) (NMR structure available (1VTXA)). Antagonist of insect voltage-gated calcium channels (Chong et al., 2007; Khan et al., 2006; Wang et al., 1999) as well as sodium channels (Luch 2010). | Eukaryota |
Metazoa, Arthropoda | Versutoxin of Hadronyche versuta (P13494) | ||
|
8.B.6.2.2 | Delta hexatoxin-Mg1a; Neurotoxin Magi-4 (105aas). Targets sites 3 and 4 of mammalian Na+ channels; slows inactivation (Yamaji et al., 2009). | Eukaryota |
Metazoa, Arthropoda | Neurotoxin Magi-4 of Macrothele gigas (P83560) | ||
|
8.B.6.2.3 | U17-barytoxin-Tl1a; U17-BATX-Tl1a; Toxin ICK-35 of 114 aas. | Eukaryota |
Metazoa, Arthropoda | U17-BATX-TI1a of Trittame loki |