9.A.14.18.1 Cytomegalovirus M78 receptor of 473 aas and 7 TMSs. It's trafficing has been studied (Sharp et al. 2009). This protein is a member of the
β-herpesvirus 'UL78 family' of seven
transmembrane receptors which are required for
efficient cell-cell spread
of the virus in tissue culture, and M78 knockout viruses
are attenuated for replication in vivo. M78 forms dimers, a property
common to several cellular
7TMR. It traffics to the cell surface but is rapidly and
constitutively endocytosed. In
MCMV-infected cells, the subcellular
localization of M78 is modified during the course of infection, which
may be related to the
incorporation of M78 into the virion envelope during the course of
virion maturation (Sharp et al. 2009). This protein is a member of the
β-herpesvirus 'UL78 family' of seven
transmembrane receptors which are required for
efficient cell-cell spread
of the virus in tissue culture, and M78 knockout viruses
are attenuated for replication in vivo. M78 forms dimers, a property
common to several cellular
7TMR. It traffics to the cell surface but is rapidly and
constitutively endocytosed. In
MCMV-infected cells, the subcellular
localization of M78 is modified during the course of infection, which
may be related to the
incorporation of M78 into the virion envelope during the course of
virion maturation (Sharp et al. 2009).
|
Accession Number: | A8E1J7 |
Protein Name: | M78 protein |
Length: | 471 |
Molecular Weight: | 51401.00 |
Species: | Murid herpesvirus 1 (strain K181) (MuHV-1) [69156] |
Number of TMSs: | 7 |
Substrate |
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1: MPTSSCAVDY SYPEVDAEHL SFIQTYNILV TSTFAVVGLI SIVLILGSLI LSMWRKVWHR
61: RNGGARIYVF SLFLAEFMYV ASFVAIWLVR VVCPSKVTEP YCRLAIMVNG MSEGAVSFFY
121: LYLTLDRLCL VGAVTEKKTI FNTSAGKDLV GVIWVTVVAW ISAFIVGAPA LTSQVMRDRA
181: GFLPVCEMQG PDDMPYVLMH VTAVYVVPFL IIISRLFEMR YSARDGTWHF VSGASIYYVM
241: YMIIVVPIII CRVVISFGEI GHSLSQTTLQ YVDLISTAGW QGRGIAVAFA CDVVVKYVEA
301: AGELHASVDG SDDRRSLCAD LPSCIYPVGT TLVKSTFGFF LKGAKTMLRL CRRVSPFGIQ
361: KDALKSPAAM KALEGAAYDN KSFSPDEDDD DKIPTVCEKT GPPPSLTEIA MTPVVDSQQK
421: MTSLPMSVFY SDGGEKEGVQ GDEGGHIIPI PPSDGVTDDV SALLPTSSSV V