9.A.14.18.1
Cytomegalovirus M78 receptor of 473 aas and 7 TMSs.  It's trafficing has been studied (Sharp et al. 2009).  This protein is a member of the β-herpesvirus 'UL78 family' of seven transmembrane receptors which are required for efficient cell-cell spread of the virus in tissue culture, and M78 knockout viruses are attenuated for replication in vivo. M78 forms dimers, a property common to several cellular 7TMR. It traffics to the cell surface but is rapidly and constitutively endocytosed.  In MCMV-infected cells, the subcellular localization of M78 is modified during the course of infection, which may be related to the incorporation of M78 into the virion envelope during the course of virion maturation (Sharp et al. 2009).  This protein is a member of the β-herpesvirus 'UL78 family' of seven transmembrane receptors which are required for efficient cell-cell spread of the virus in tissue culture, and M78 knockout viruses are attenuated for replication in vivo. M78 forms dimers, a property common to several cellular 7TMR. It traffics to the cell surface but is rapidly and constitutively endocytosed.  In MCMV-infected cells, the subcellular localization of M78 is modified during the course of infection, which may be related to the incorporation of M78 into the virion envelope during the course of virion maturation (Sharp et al. 2009).