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Accession Number: | Q16602 |
Protein Name: | Calcitonin gene-related peptide type 1 receptor |
Length: | 461 |
Molecular Weight: | 52929.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
Cross database links:
DIP: | DIP-37674N |
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Entrez Gene ID: | 10203 |
Pfam: | PF00002 PF02793 |
KEGG: | hsa:10203 |
Gene Ontology
GO:0005783
C:endoplasmic reticulum
GO:0005768
C:endosome
GO:0005887
C:integral to plasma membrane
GO:0005764
C:lysosome
GO:0001605
F:adrenomedullin receptor activity
GO:0001635
F:calcitonin gene-related polypeptide receptor activity
GO:0004948
F:calcitonin receptor activity
GO:0008565
F:protein transporter activity
GO:0007189
P:adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0001525
P:angiogenesis
GO:0006816
P:calcium ion transport
GO:0006171
P:cAMP biosynthetic process
GO:0071329
P:cellular response to sucrose stimulus
GO:0007187
P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007507
P:heart development
GO:0050728
P:negative regulation of inflammatory response
GO:0030819
P:positive regulation of cAMP biosynthetic process
GO:0048661
P:positive regulation of smooth muscle cell proliferation
GO:0031623
P:receptor internalization
GO:0006937
P:regulation of muscle contraction
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References (7)[1] “A cDNA encoding the calcitonin gene-related peptide type 1 receptor.” Aiyar N.et.al. 8626685 [2] “A human orphan calcitonin receptor-like structure.” Fluehmann B.et.al. 7818539 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [5] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.” Zhang Z.et.al. 15340161 [6] “Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.” ter Haar E.et.al. 20826335 [7] “Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.” Kusano S.et.al. 22102369
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Structure: | |
[...more] |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MEKKCTLNFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ KIMQDPIQQA 61: EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK VTKICDQDGN WFRHPASNRT 121: WTNYTQCNVN THEKVKTALN LFYLTIIGHG LSIASLLISL GIFFYFKSLS CQRITLHKNL 181: FFSFVCNSVV TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL 241: IVVAVFAEKQ HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA 301: ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LIPWRPEGKI 361: AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNSF SNSEALRSAS 421: YTVSTISDGP GYSHDCPSEH LNGKSIHDIE NVLLKPENLY N