TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.14.5.1
Cyclic AMP receptor 1

Accession Number:P13773
Protein Name:Cyclic AMP receptor 1
Length:392
Molecular Weight:44312.00
Species:Dictyostelium discoideum (Slime mold) [44689]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Entrez Gene ID: 8618967    8619010   
KEGG: ddi:DDB_G027339    ddi:DDB_G027353    ddi:DDB_G027339    ddi:DDB_G027353   

Gene Ontology

GO:0009986 C:cell surface
GO:0005887 C:integral to plasma membrane
GO:0030552 F:cAMP binding
GO:0001646 F:cAMP receptor activity
GO:0001637 F:G-protein coupled chemoattractant receptor activity
GO:0007190 P:activation of adenylate cyclase activity
GO:0032148 P:activation of protein kinase B activity
GO:0031152 P:aggregation involved in sorocarp development
GO:0006935 P:chemotaxis
GO:0002029 P:desensitization of G-protein coupled receptor protein signaling pathway
GO:0050764 P:regulation of phagocytosis
GO:0046578 P:regulation of Ras protein signal transduction

References (50)

[1] “A chemoattractant receptor controls development in Dictyostelium discoideum.”  Klein P.S.et.al.   3047871
[2] “Sequence and analysis of chromosome 2 of Dictyostelium discoideum.”  Gloeckner G.et.al.   12097910
[3] “The genome of the social amoeba Dictyostelium discoideum.”  Eichinger L.et.al.   15875012
[4] “Surface cAMP receptors mediate multiple responses during development in Dictyostelium: evidenced by antisense mutagenesis.”  Sun T.J.et.al.   1692327
[5] “Expression of a cAMP receptor gene of Dictyostelium and evidence for a multigene family.”  Saxe C.L. IIIet.al.   1989903
[6] “Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium.”  Sun T.J.et.al.   1849108
[7] “Two transmembrane signaling mechanisms control expression of the cAMP receptor gene CAR1 during Dictyostelium development.”  Louis J.M.et.al.   8392183
[8] “Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two subtypes of early cAMP receptors (cARs). Evidence for involvement of cAR1 in aggregative gene expression.”  Soede R.D.M.et.al.   7925004
[9] “Precise expression of the cAMP receptor gene, CAR1, during transition from growth to differentiation in Dictyostelium discoideum.”  Abe F.et.al.   8150078
[10] “Localization of ligand-induced phosphorylation sites to serine clusters in the C-terminal domain of the Dictyostelium cAMP receptor, cAR1.”  Hereld D.et.al.   8120068
[11] “Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a reduction in affinity which depends upon COOH-terminal serine residues.”  Caterina M.J.et.al.   7876207
[12] “Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation.”  Xiao Z.et.al.   9334341
[13] “Agonist-induced loss of ligand binding is correlated with phosphorylation of cAR1, a G protein-coupled chemoattractant receptor from Dictyostelium.”  Caterina M.J.et.al.   7721769
[14] “Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses.”  Kim J.-Y.et.al.   9341180
[15] “Switching of chemoattractant receptors programs development and morphogenesis in Dictyostelium: receptor subtypes activate common responses at different agonist concentrations.”  Kim J.-Y.et.al.   9578623
[16] “Desensitization of G-protein-coupled receptors. agonist-induced phosphorylation of the chemoattractant receptor cAR1 lowers its intrinsic affinity for cAMP.”  Xiao Z.et.al.   9880518
[17] “The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation.”  Briscoe C.et.al.   11319871
[18] “Spatial expression patterns of genes involved in cyclic AMP responses in Dictyostelium discoideum development.”  Tsujioka M.et.al.   11422293
[19] “cAMP receptor affinity controls wave dynamics, geometry and morphogenesis in Dictyostelium.”  Dormann D.et.al.   11559759
[20] “A transcriptional profile of multicellular development in Dictyostelium discoideum.”  Van Driessche N.et.al.   11923193
[21] “Changing patterns of gene expression in Dictyostelium prestalk cell subtypes recognized by in situ hybridization with genes from microarray analyses.”  Maeda M.et.al.   12796308
[22] “Genome-wide expression analyses of gene regulation during early development of Dictyostelium discoideum.”  Iranfar N.et.al.   12912885
[23] “Control of cell type proportioning in Dictyostelium discoideum by differentiation-inducing factor as determined by in situ hybridization.”  Maruo T.et.al.   15470253
[24] “Constitutively active G protein-coupled receptor mutants block dictyostelium development.”  Zhang M.et.al.   15574880
[25] “Regulation of G protein-coupled cAMP receptor activation by a hydrophobic residue in transmembrane helix 3.”  Zhang M.et.al.   17630977
[26] “A chemoattractant receptor controls development in Dictyostelium discoideum.”  Klein P.S.et.al.   3047871
[27] “Sequence and analysis of chromosome 2 of Dictyostelium discoideum.”  Gloeckner G.et.al.   12097910
[28] “The genome of the social amoeba Dictyostelium discoideum.”  Eichinger L.et.al.   15875012
[29] “Surface cAMP receptors mediate multiple responses during development in Dictyostelium: evidenced by antisense mutagenesis.”  Sun T.J.et.al.   1692327
[30] “Expression of a cAMP receptor gene of Dictyostelium and evidence for a multigene family.”  Saxe C.L. IIIet.al.   1989903
[31] “Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium.”  Sun T.J.et.al.   1849108
[32] “Two transmembrane signaling mechanisms control expression of the cAMP receptor gene CAR1 during Dictyostelium development.”  Louis J.M.et.al.   8392183
[33] “Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two subtypes of early cAMP receptors (cARs). Evidence for involvement of cAR1 in aggregative gene expression.”  Soede R.D.M.et.al.   7925004
[34] “Precise expression of the cAMP receptor gene, CAR1, during transition from growth to differentiation in Dictyostelium discoideum.”  Abe F.et.al.   8150078
[35] “Localization of ligand-induced phosphorylation sites to serine clusters in the C-terminal domain of the Dictyostelium cAMP receptor, cAR1.”  Hereld D.et.al.   8120068
[36] “Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a reduction in affinity which depends upon COOH-terminal serine residues.”  Caterina M.J.et.al.   7876207
[37] “Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation.”  Xiao Z.et.al.   9334341
[38] “Agonist-induced loss of ligand binding is correlated with phosphorylation of cAR1, a G protein-coupled chemoattractant receptor from Dictyostelium.”  Caterina M.J.et.al.   7721769
[39] “Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses.”  Kim J.-Y.et.al.   9341180
[40] “Switching of chemoattractant receptors programs development and morphogenesis in Dictyostelium: receptor subtypes activate common responses at different agonist concentrations.”  Kim J.-Y.et.al.   9578623
[41] “Desensitization of G-protein-coupled receptors. agonist-induced phosphorylation of the chemoattractant receptor cAR1 lowers its intrinsic affinity for cAMP.”  Xiao Z.et.al.   9880518
[42] “The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation.”  Briscoe C.et.al.   11319871
[43] “Spatial expression patterns of genes involved in cyclic AMP responses in Dictyostelium discoideum development.”  Tsujioka M.et.al.   11422293
[44] “cAMP receptor affinity controls wave dynamics, geometry and morphogenesis in Dictyostelium.”  Dormann D.et.al.   11559759
[45] “A transcriptional profile of multicellular development in Dictyostelium discoideum.”  Van Driessche N.et.al.   11923193
[46] “Changing patterns of gene expression in Dictyostelium prestalk cell subtypes recognized by in situ hybridization with genes from microarray analyses.”  Maeda M.et.al.   12796308
[47] “Genome-wide expression analyses of gene regulation during early development of Dictyostelium discoideum.”  Iranfar N.et.al.   12912885
[48] “Control of cell type proportioning in Dictyostelium discoideum by differentiation-inducing factor as determined by in situ hybridization.”  Maruo T.et.al.   15470253
[49] “Constitutively active G protein-coupled receptor mutants block dictyostelium development.”  Zhang M.et.al.   15574880
[50] “Regulation of G protein-coupled cAMP receptor activation by a hydrophobic residue in transmembrane helix 3.”  Zhang M.et.al.   17630977

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MGLLDGNPAN ETSLVLLLFA DFSSMLGCMA VLIGFWRLKL LRNHVTKVIA CFCATSFCKD 
61:	FPSTILTLTN TAVNGGFPCY LYAIVITYGS FACWLWTLCL AISIYMLIVK REPEPERFEK 
121:	YYYLLCWGLP LISTIVMLAK NTVQFVGNWC WIGVSFTGYR FGLFYGPFLF IWAISAVLVG 
181:	LTSRYTYVVI HNGVSDNKEK HLTYQFKLIN YIIVFLVCWV FAVVNRIVNG LNMFPPALNI 
241:	LHTYLSVSHG FWASVTFIYN NPLMWRYFGA KILTVFTFFG YFTDVQKKLE KNKNNNNPSP 
301:	YSSSRGTSGK TMGGHPTGDD VQCSSDMEQC SLERHPNMVN NQQNLNNNYG LQQNYNDEGS 
361:	SSSSLSSSDE EKQTVEMQNI QISTSTNGQG NN