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9.B.188.1.4
Transmembrane emp24 domain-containing protein 10 precursor, Tmed10 or TMP21, of 219 aas and 2 TMSs, N- and C-terminal. It is involved in vesicular protein trafficking in the early secretory pathway, probably as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles (Luo et al. 2011). The TMP21 transmembrane domain promotes its association with the presenilin complex that results in decreased gamma-cleavage activity (Pardossi-Piquard et al. 2009). Thus, TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity (Chen et al. 2006). TMP21 modulates cell growth of papillary thyroid cancer cells by inducing autophagy through activation of the AMPK/mTOR pathway (Xu et al. 2015).  

Accession Number:P49755
Protein Name:Transmembrane emp24 domain-containing protein 10
Length:219
Molecular Weight:24976.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Golgi apparatus1 / Single-pass type I membrane protein2
Substrate

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FASTA formatted sequence
1:	MSGLSGPPAR RGPFPLALLL LFLLGPRLVL AISFHLPINS RKCLREEIHK DLLVTGAYEI 
61:	SDQSGGAGGL RSHLKITDSA GHILYSKEDA TKGKFAFTTE DYDMFEVCFE SKGTGRIPDQ 
121:	LVILDMKHGV EAKNYEEIAK VEKLKPLEVE LRRLEDLSES IVNDFAYMKK REEEMRDTNE 
181:	STNTRVLYFS IFSMFCLIGL ATWQVFYLRR FFKAKKLIE