9.B.188.1.4
Transmembrane emp24 domain-containing protein 10 precursor, Tmed10 or TMP21, of 219 aas and 2 TMSs, N- and C-terminal. It is involved in vesicular protein trafficking in the early secretory pathway, probably as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles (Luo et al. 2011). The TMP21 transmembrane domain promotes its association with the presenilin complex that results in decreased gamma-cleavage activity (Pardossi-Piquard et al. 2009). Thus, TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity (Chen et al. 2006). TMP21 modulates cell growth of papillary thyroid cancer cells by inducing autophagy through activation of the AMPK/mTOR pathway (Xu et al. 2015). TMED2 may regulate inflammation in lung adenocarcinoma (LUAD) through the TLR4/NF-kappaB signaling pathway and enhance the proliferation, development, and prognosis of LUAD by regulating inflammation (Feng et al. 2022). It is present in alterred amounts upon acute kidney damage following Covid-19 infection (Paranjpe et al. 2023).  Transmembrane p24 trafficking protein 10 (TMED10) inhibits mitochondrial damage and protects neurons in ischemic stroke via the c-Jun N-terminal kinase (JNK) signaling pathway (Li et al. 2023). TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation (Li et al. 2023).