9.B.310.  The Putative K+ Channel Protein (K+Ch) Family 

A viral protein of 100 aas and 2 TMSs represent the founding member of this family. ORF A201L from chlorovirus NY-2A (accession #YP_001497468.1) was able to rescue a yeast mutant that lacked K⁺ uptake porters and channels. The results of these experiments suggested that this protein has K⁺ channel activity (Greiner et al. 2018). The positive rescue of growth by ORF A201L can be interpreted as evidence for a channel function for this protein. However, the electrophysiological characterization in HEK293 cells did not result in a robust K⁺ channel function (Greiner et al. 2018).