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9.B.310.  The Putative K+ Channel Protein (K+Ch) Family 

A viral protein of 100 aas and 2 TMSs represent the founding member of this family. ORF A201L from chlorovirus NY-2A (accession #YP_001497468.1) was able to rescue a yeast mutant that lacked K+ uptake porters and channels. The results of these experiments suggested that this protein has K+ channel activity (Greiner et al. 2018). The positive rescue of growth by ORF A201L can be interpreted as evidence for a channel function for this protein. However, the electrophysiological characterization in HEK293 cells did not result in a robust K+ channel function (Greiner et al. 2018).

References associated with 9.B.310 family:

Greiner, T., A. Moroni, J.L. Van Etten, and G. Thiel. (2018). Genes for Membrane Transport Proteins: Not So Rare in Viruses. Viruses 10:. 30149667