9.B.311.2.1
TRAM1 of 374 aas and 6 - 8 TMSs, possibly in a 3 + 3 TMS arrangement. The translocating chain-associated membrane protein (TRAM1) was proposed to support transport of a subset of protein precursors, but this may not be true (Klein et al. 2020). TRAM1 depletion did not affect calcium leakage from the ER. TRAM1 does not appear to affect the open probability of the Sec61-channel and may rather play a supportive role in protein transport, such as making the phospholipid bilayer conducive in the vicinity of the lateral gate of the Sec61-channel (Klein et al. 2020).
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| Accession Number: | Q15629 |
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| Protein Name: | Translocating chain-associated membrane protein 1 |
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| Length: | 374 |
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| Molecular Weight: | 43072.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MAIRKKSTKS PPVLSHEFVL QNHADIVSCV AMVFLLGLMF EITAKASIIF VTLQYNVTLP
61: ATEEQATESV SLYYYGIKDL ATVFFYMLVA IIIHAVIQEY MLDKINRRMH FSKTKHSKFN
121: ESGQLSAFYL FACVWGTFIL ISENYISDPT ILWRAYPHNL MTFQMKFFYI SQLAYWLHAF
181: PELYFQKTKK EDIPRQLVYI GLYLFHIAGA YLLNLNHLGL VLLVLHYFVE FLFHISRLFY
241: FSNEKYQKGF SLWAVLFVLG RLLTLILSVL TVGFGLARAE NQKLDFSTGN FNVLAVRIAV
301: LASICVTQAF MMWKFINFQL RRWREHSAFQ APAVKKKPTV TKGRSSKKGT ENGVNGTLTS
361: NVADSPRNKK EKSS