TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.311.1.1









Protein FAM57A isoform X2 of 257 aas and 7 TMSs.

Eukaryota
Metazoa, Chordata
FAM57A protein of Piliocolobus tephrosceles
9.B.311.1.2









Protein FAM57A isoform 1 of 257 aas and 7 TMSs.

Eukaryota
Metazoa, Chordata
FAM57A protein of Homo sapiens
9.B.311.1.3









Uncharacterized protein of 323 aas and 6 or 7 TMSs.

Eukaryota
Fungi, Ascomycota
UP of Glonium stellatum
9.B.311.1.4









Uncharacterized protein of 299 aas and 6 or 7 TMSs.

Eukaryota
Viridiplantae, Chlorophyta
UP of Coccomyxa subellipsoidea
9.B.311.1.5









Uncharacterized protein of 287 aas and 6 or 7 TMSs.

Eukaryota
Rhodophyta
UP of Galdieria sulphuraria
9.B.311.1.6









Transmembrane protein 56-B of 256 aas and 6 or 7 TM

Eukaryota
Metazoa, Chordata
TMEM56-A of Oryzias latipes
9.B.311.1.7









Transmembrane protein 56-like isoform X1of 271 aas and 6 TMSs.

Eukaryota
Viridiplantae, Streptophyta
TMEM56 of Brassica napus
9.B.311.1.8









Protein CLN8 of 285 aas and 7 TM

Eukaryota
Metazoa, Chordata
CLN8 of Columba livia
9.B.311.1.9









Calfacilitin isoform X2 of 248 aas and 6 TM

Eukaryota
Metazoa, Brachiopoda
Calfacilitin of Lingula anatina
9.B.311.1.10









Transmembrane protein 136-like isoform X2 of 244 aas and 6 TM

Eukaryota
Metazoa, Echinodermata
136 of Acanthaster planci
9.B.311.1.11









Transmembrane protein 56 of 254 aas and 6 or 7 TMSs.

Eukaryota
Ciliophora
TMEM56 of Stylonychia lemnae
9.B.311.1.12









Transmembrane protein 136-like isoform X2 of 221 aas and 7 TMSs.  It has TRAM, LAG1 and CLN8 (TLC) lipid-sensing domains.

Eukaryota
Viridiplantae, Streptophyta
TMEM136 of Durio zibethinus
9.B.311.1.13









TLC domain-containing protein 2 of 244 aas and 5 TM

Eukaryota
Metazoa, Chordata
TLC domain protein of Apteryx rowi
9.B.311.1.14









Uncharacterized TRAM/LAG1/CLN8-like domain-containing proteinof 672 aas and ~14 TMSs. This protein contains an internal repeat where TMSs 1 - 6 resemble TMSs 7-12.

Eukaryota
Viridiplantae, Streptophyta
UP of Artemisia annua
9.B.311.1.15









Uncharacterizxed protein of 435 aas and 7 TMSs

Eukaryota
Apicomplexa
UP of Toxoplasma gondii
9.B.311.1.16









Uncharacterized protein of 269 aas and 6 TMSs.

Eukaryota
Ciliophora
UP of Paramecium tetraurelia
9.B.311.1.17









Transmembrane protein 56-like C of 167 aas and 6 TMSs

Eukaryota
TMEM67 of Hondaea fermentalgiana
9.B.311.1.18









Uncharacterized protein of 381 aas and 7 TMSs in a 1 + 6 arrangement with a 150 aa hydrophilic domain between TMSs 1 and 2.

Eukaryota
Viridiplantae, Chlorophyta
UP of Chlamydomonas reinhardtii
9.B.311.1.19









Ceramide synthase 6 isoform X1 of 381 aas and 7 TMSs.

Eukaryota
Metazoa, Brachiopoda
Ceremide synthase of Lingula anatina
9.B.311.1.20









Ceramide synthase 1 of 274 aas and 6 TM

Eukaryota
Metazoa, Chordata
Ceramide synthase of Amphiprion ocellaris
9.B.311.1.21









LAG1 longevity assurance protein of 355 aas and 6 TMSs.

Eukaryota
Ciliophora
LAG1 of Oxytricha trifallax
9.B.311.1.22









Uncharacterized protein of 1573 aas and 6 C-terminal TMSs.

Eukaryota
Oomycota
UP of Albugo candida
9.B.311.1.23









Uncharacterized TLC domain-containing protein 2 of 260 aas and 6 TMSs.

Eukaryota
Metazoa, Mollusca
UP of Crassostrea gigas
9.B.311.1.24









Uncharacterized protein of 382 aas and 6 TMSs.

Eukaryota
Evosea
UP of Dictyostelium purpureum
9.B.311.1.25









Uncharacterized protein of 317 aas and ~ 7 TMSs.

Eukaryota
Bacillariophyta
UP of Thalassiosira oceanica
9.B.311.1.26









Uncharacterized protein of 276 aas and 6 TMSs.

Eukaryota
Ciliophora
UP of Oxytricha trifallax
9.B.311.1.27









Uncharacterized protein of 175 aas and 7 TMSs.

Eukaryota
Rhodophyta
UP of Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
9.B.311.1.28









Uncharacterized protein of 315 aas and 6 TMSs.

Eukaryota
Haptophyta
UP of Emiliania huxleyi
9.B.311.1.29









Sphingosine N-acyltransferase lac1of 452 aas and 6 TMSs.

Eukaryota
Fungi, Basidiomycota
N-acyltransferase of Leucoagaricus sp. SymC.cos
9.B.311.1.30









Uncharacterized protein of 278 aas and 6 TMSs

Eukaryota
Metazoa, Nematoda
UP of Caenorhabditis elegans
9.B.311.1.32









Sphingosine N-acyltransferase, lac1, of 475 aas and 7 TMSs in a 6 + 1 TMS arrangement. It may also be a sugar transporter, Lac1, in the ER.  It is essential for cellulase production and biomass formation by affecting protein processing in the ER (particularly protein glycosylation) and lipid biosynthesis. The effect of LAC1 on cellulase production seems to be post-transcriptional at a late stage of cellulase production, independent on the well-known cellulase regulation mediated by CRT1 and XYR1 (Wang et al. 2022).

Eukaryota
Fungi, Ascomycota
Lac1 of Trichoderma parareesei
9.B.311.2.1









TRAM1 of 374 aas and 6 - 8 TMSs, possibly in a 3 + 3 TMS arrangement. The translocating chain-associated membrane protein (TRAM1) was proposed to support transport of a subset of protein precursors, but this may not be true (Klein et al. 2020). TRAM1 depletion did not affect calcium leakage from the ER. TRAM1 does not appear to affect the open probability of the Sec61-channel and may rather play a supportive role in protein transport, such as making the phospholipid bilayer conducive in the vicinity of the lateral gate of the Sec61-channel (Klein et al. 2020).

Eukaryota
Metazoa, Chordata
TRAM1 of Homo sapiens
9.B.311.2.2









Uncharacterized protein of 172 aas and 3 TMSs

Eukaryota
Metazoa, Nematoda
UP of Brugia timori
9.B.311.2.3









TRAML1 of 369 aas and 3 TMSs

Eukaryota
Metazoa, Chordata
TRAML1 of Homo sapiens
9.B.311.2.4









Translocating chain-associated membrane protein 2, TRAM2, of 370 aas and 3 TMSs. It interacts with SERCA2b (Stefanovic et al. 2004). TRAM2 , a membrane protein containing a putative ceramide-interacting domain. It plays a role in membrane insertion of integral membrane proteins, influencing their topologies (Chen et al. 2016).

Eukaryota
Metazoa, Chordata
TRAM2 of Homo sapiens