9.b.313. The 7 TMS Cir5 Domain-containing Protein (7DCP) Family
The members of the 7DCP family usually contain about 400 aas (350 - 450 aas) with 7 TMSs, although some appear to be smaller and have 5 or 6 TMSs, possibly due to incomplete sequences. These domains can be present as fusion domains in other proteins such as MFS (FucP-like; see 2.A.1.7.25) proteins, and enzymes such as aminotransferases. When they are fused to other protein domains, they are usually the N-terminal domain. Their functions do not seem to be known, and CDD does not identify these proteins/domains although this is a huge family of eukaryotic proteins. Members are numberous and are present primarily in fungi (Kulkarni et al. 2005).