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9.B.385.  The TMEM39A or SUSR2 (TMEM39A) Family 

Transmembrane Protein 39A (TMEM39A) is a mediator of autoimmune disease. It seems to be involved in systemic lupus erythematosus and multiple sclerosis in humans. Tran et al. 2017 reviewed the current knowledge about TMEM39A and its possible roles in cell biology, physiology and pathology. It may play a role in brain tumors (Park et al. 2017). TMEM39A gene polymorphisms are related to various autoimmune diseases including autoimmune thyroid disease (Yao et al. 2019). It is an ER-localized transmembrane protein that acts as an adaptor protein for efficient export of proteins such as SAC1 from the ER (Miao et al. 2020). TMEM39a promotes the replication of encephalomyocarditis virus via an autophagy pathway (Li et al. 2019). A myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death (Park et al. 2020) (see TC# 1.D.124). The conserved autoimmune-disease risk gene TMEM39A regulates lysosomal dynamics (Luo et al. 2021). It also coordinates with COPII to promote collagen secretion and regulate the ER stress response (Park et al. 2020) (see TC# 1.D.124). The conserved autoimmune-disease risk gene TMEM39A regulates lysosomal dynamics (Luo et al. 2021). It also coordinates with COPII to promote collagen secretion and regulate the ER stress response (Zhang et al. 2021).

References associated with 9.B.385 family:

Li, X., R. Ma, Q. Li, S. Li, H. Zhang, J. Xie, J. Bai, A. Idris, and R. Feng. (2019). Transmembrane Protein 39A Promotes the Replication of Encephalomyocarditis Virus Autophagy Pathway. Front Microbiol 10: 2680. 31849860
Luo, S., X. Wang, M. Bai, W. Jiang, Z. Zhang, Y. Chen, and D.K. Ma. (2021). The conserved autoimmune-disease risk gene regulates lysosome dynamics. Proc. Natl. Acad. Sci. USA 118:. 33531362
Miao, G., Y. Zhang, D. Chen, and H. Zhang. (2020). The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1. Mol. Cell 77: 618-632.e5. 31806350
Park, J., H. Lee, Q. Tran, K. Mun, D. Kim, Y. Hong, S.H. Kwon, D. Brazil, J. Park, and S.H. Kim. (2017). Recognition of Transmembrane Protein 39A as a Tumor-Specific Marker in Brain Tumor. Toxicol Res 33: 63-69. 28133515
Park, S., M. Kim, Y. Hong, H. Lee, Q. Tran, C. Kim, S.H. Kwon, J. Park, J. Park, and S.H. Kim. (2020). Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death. Toxicol Res 36: 123-130. 32257924
Tran, Q., J. Park, H. Lee, Y. Hong, S. Hong, S. Park, J. Park, and S.H. Kim. (2017). TMEM39A and Human Diseases: A Brief Review. Toxicol Res 33: 205-209. 28744351
Yao, Q., B. Wang, Q. Qin, X. Jia, L. Li, and J.A. Zhang. (2019). Genetic Variants in Gene Are Associated with Autoimmune Thyroid Diseases. DNA Cell Biol 38: 1249-1256. 31553233
Zhang, Z., S. Luo, G.O. Barbosa, M. Bai, T.B. Kornberg, and D.K. Ma. (2021). The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. PLoS Genet 17: e1009317. 33524011