9.B.385.1.1
The TMEM39A or SUSR2 protein of 488 aas and 8 TMSs in a 4 + 2 + 2 TMS arrangement. It plays a role in cell physiology and pathology (see the family description). A cell penetrating peptide has been derived from it (see TC# 1.D.124). The ER-localized TMEM39A/SUSR2 regulates autophagy by controlling trafficking of the PtdIns(4)P phosphatase SAC1 (Miao et al. 2020).
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| Accession Number: | Q9NV64 |
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| Protein Name: | Transmembrane protein 39A |
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| Length: | 488 |
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| Molecular Weight: | 55667.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MPGGRRGPSR QQLSRSALPS LQTLVGGGCG NGTGLRNRNG SAIGLPVPPI TALITPGPVR
61: HCQIPDLPVD GSLLFEFLFF IYLLVALFIQ YINIYKTVWW YPYNHPASCT SLNFHLIDYH
121: LAAFITVMLA RRLVWALISE ATKAGAASMI HYMVLISARL VLLTLCGWVL CWTLVNLFRS
181: HSVLNLLFLG YPFGVYVPLC CFHQDSRAHL LLTDYNYVVQ HEAVEESAST VGGLAKSKDF
241: LSLLLESLKE QFNNATPIPT HSCPLSPDLI RNEVECLKAD FNHRIKEVLF NSLFSAYYVA
301: FLPLCFVKST QYYDMRWSCE HLIMVWINAF VMLTTQLLPS KYCDLLHKSA AHLGKWQKLE
361: HGSYSNAPQH IWSENTIWPQ GVLVRHSRCL YRAMGPYNVA VPSDVSHARF YFLFHRPLRL
421: LNLLILIEGS VVFYQLYSLL RSEKWNHTLS MALILFCNYY VLFKLLRDRI VLGRAYSYPL
481: NSYELKAN