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The TMEM88 (TMEM88) Family 

The TMEM88 family consists of small proteins of about 150 aas and 2 centrally located TMSs. The dishevelled (Dvl/Dsh) protein is one of the key components in Wnt signaling and plays essential roles in regulating these pathways through protein-protein interactions. TMEM88 binds to the Dishevelled (Dvl/Dsh) protein, one of key components in Wnt signaling that plays essential roles in regulating these pathways through protein-protein interactions (Lee et al. 2010). TMEM88 attenuates the Wnt/β-catenin signaling induced by Wnt-1 ligands, and miRNA-708 acts as an oncogene contributing to tumor growth and disease progression by directly downregulating TMEM88 (Jang et al. 2012). TMEM88 also promotes triple-negative breast vancer by interacting With Dvl (Yu et al. 2015). TMEM88 mediates inflammatory cytokines secretion (Xu et al. 2018; Li et al. 2020).

References associated with 9.B.389 family:

Jang, J.S., H.S. Jeon, Z. Sun, M.C. Aubry, H. Tang, C.H. Park, F. Rakhshan, D.A. Schultz, C.P. Kolbert, R. Lupu, J.Y. Park, C.C. Harris, P. Yang, and J. Jen. (2012). Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers. Clin Cancer Res 18: 3658-3667. 22573352
Lee, H.J., D. Finkelstein, X. Li, D. Wu, D.L. Shi, and J.J. Zheng. (2010). Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J. Biol. Chem. 285: 41549-41556. 21044957
Li, L.Y., C.C. Yang, S.W. Li, Y.M. Liu, H.D. Li, S. Hu, H. Zhou, J.L. Wang, H. Shen, X.M. Meng, J. Li, and T. Xu. (2020). TMEM88 modulates the secretion of inflammatory factors by regulating YAP signaling pathway in alcoholic liver disease. Inflamm Res. [Epub: Ahead of Print] 32451556
Xu, T., L. Pan, L. Li, S. Hu, H. Zhou, C. Yang, J. Yang, H. Li, Y. Liu, X. Meng, and J. Li. (2020). MicroRNA-708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88. J Cell Mol Med. [Epub: Ahead of Print] 32463570
Xu, T., L.X. Pan, Y.X. Ge, P. Li, X.M. Meng, C. Huang, and J. Li. (2018). TMEM88 mediates inflammatory cytokines secretion by regulating JNK/P38 and canonical Wnt/β-catenin signaling pathway in LX-2 cells. Inflammopharmacology 26: 1339-1348. 29159713
Yu, X., X. Zhang, Y. Zhang, G. Jiang, X. Mao, and F. Jin. (2015). Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl. Oncotarget 6: 25034-25045. 26325443