9.B.413. The TMEM119 (TMEM119) Family
TMEM119 plays an important role in bone formation and
normal bone mineralization and promotes the differentiation of myoblasts
into osteoblasts (Kanamoto et al. 2009). It may induce the commitment and differentiation of myoblasts into
osteoblasts through an enhancement of BMP2 production and interaction
with the BMP-RUNX2 pathway. It also upregulates the expression of ATF4, a
transcription factor which plays a central role in osteoblast
differentiation, and is essential for normal spermatogenesis and late
testicular differentiation. It is a cell surface biomarker for microglia (Kumar et al. 2021).
References associated with 9.B.413 family:
Kanamoto, T., K. Mizuhashi, K. Terada, T. Minami, H. Yoshikawa, and T. Furukawa. (2009). Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev Biol 9: 70. 20025746
Kumar, A., S. Kim, Y. Su, M. Sharma, P. Kumar, S. Singh, J. Lee, C.M. Furdui, R. Singh, F.C. Hsu, J. Kim, C.T. Whitlow, M.A. Nader, and G. Deep. (2021). Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone. EBioMedicine 63: 103192. 33418508
Raven, J.A. (2020). Determinants, and implications, of the shape and size of thylakoids and cristae. J Plant Physiol. 257: 153342. [Epub: Ahead of Print] 33385618