9.B.434. The Adipogenin (Adig) Family
Up-regulation of adipogenin (Adig), an adipocyte plasma transmembrane protein of 80 aas and one N-terminal TMS during adipogenesis, has been documented (Hong et al. 2005). Characterization of Adig null mice has suggested roles for adipogenin in the regulation of fat mass accrual and leptin secretion (Alvarez-Guaita et al. 2021). The gene for ADIG (also known as the Small Adipocyte Factor 1) is highly upregulated during 3T3-L1 in vitro adipogenesis, and it is markedly enriched in adipose tissues. Its expression in 3T3-L1 adipocytes is positively regulated by insulin and glucose. (Ren et al. 2016). Adipogenin overexpression enhances fat accumulation of bovine myosatellite cells (Liu et al. 2017).
References associated with 9.B.434 family:
Alvarez-Guaita, A., S. Patel, K. Lim, A. Haider, L. Dong, O.J. Conway, M.K.L. Ma, D. Chiarugi, V. Saudek, S. O''Rahilly, and D.B. Savage. (2021). Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion. Cell Rep 34: 108810. 33691105
Hong, Y.H., D. Hishikawa, H. Miyahara, H. Tsuzuki, Y. Nishimura, C. Gotoh, K.C. Choi, Y. Hokari, Y. Takagi, H.G. Lee, K.K. Cho, S.G. Roh, and S. Sasaki. (2005). Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. Mol. Cell Biochem 276: 133-141. 16132694
Liu, Y., B. Jiang, C. Fu, and R. Hao. (2017). Cloning and characterization of adipogenin and its overexpression enhances fat accumulation of bovine myosatellite cells. Gene 601: 27-35. 27914980
Ren, G., P. Eskandari, S. Wang, and C.M. Smas. (2016). Expression, regulation and functional assessment of the 80 amino acid Small Adipocyte Factor 1 (Smaf1) protein in adipocytes. Arch Biochem Biophys 590: 27-36. 26427354
Zhao, N., S. Ming, L. Sun, B. Wang, H. Li, X. Zhang, and X. Zhao. (2021). Identification and Characterization of Microneme Protein (EtMIC8). Microbiol Spectr 9: e0022821. 34479414