1.A.14.3.14
GRINA (Lifguard 1, LFG1, NMDARA1, TMBIM3) has 371 aas and 7 C-terminal TMSs. It is expressed in 218 organ(s) with highest expression in the right hemisphere of the cerebellum. It is involved in ER Ca2+ ion homeostasis and regulates apoptosis. The expression of the pro-apoptotic protein Bax is upregulated, whereas the anti-apoptotic protein Bcl-2 is downregulated in GRINA silenced cells (Xu et al. 2018). Grina/TMBIM3 modulates NMDA receptors and voltage-gated CaV2.2 Ca2+ channels (TC# 1.A.1.11.9) in a G-protein-like manner (Mallmann et al. 2019). GRINA encodes the ionotropic glutamate receptor TMBIM3 (transmembrane BAX inhibitor 1 motif-containing protein family member 3), which regulates cell survival (Rice et al. 2019).
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| Accession Number: | Q7Z429 |
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| Protein Name: | Protein lifeguard 1 |
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| Length: | 371 |
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| Molecular Weight: | 41203.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cation, calcium ion |
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1: MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS PYGQPGYPHG
61: PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPQVF
121: PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV
181: SVFTFVAEVK GFVRENVWTY YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY
241: MVGMIASFYN TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC
301: IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN LYTDIINIFL
361: YILTIIGRAK E