1.C.137. The Bacterial Gasdermin (B-Gas) Family
It is the precursor of a pore-forming protein involved in defense against bacteriophages. Expression of bGSDM and the neighboring protease gene (Ga0098714_109514) is toxic in E. coli on solid medium (Johnson et al. 2022). Cleavage of this precursor by its dedicated protease releases the active moiety (gasdermin bGSDM, N-terminus), which inserts into membranes, forming pores and triggering cell death. Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation (Liu et al. 2024). Gasdermin B (encoded by the GSDMB gene) plays a role in respiratory virus-induced lung inflammation.
This family belongs to the: Gasdermin Superfamily.
References associated with 1.C.137 family:
Johnson, A.G., T. Wein, M.L. Mayer, B. Duncan-Lowey, E. Yirmiya, Y. Oppenheimer-Shaanan, G. Amitai, R. Sorek, and P.J. Kranzusch. (2022). Bacterial gasdermins reveal an ancient mechanism of cell death. Science 375: 221-225. 35025633
Liu, T., S. Liu, X. Rui, Y. Cao, J. Hecker, F. Guo, Y. Zhang, L. Gong, Y. Zhou, Y. Yu, N. Krishnamoorthyni, S. Bates, S. Chun, N. Boyer, S. Xu, J.A. Park, M.A. Perrella, B.D. Levy, S.T. Weiss, H. Mou, B.A. Raby, and X. Zhou. (2024). Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation. Eur Respir J 63:. 38514093