| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
4.H.1.1.1 | The 14 TMS FmtC (MprF: Multiple peptide resistance factor) protein of 840 aas, involved in methicillin and daptomycin resistance. Residues 1-550 comprise a 14TMS MFS permease domain while residues 551-840 comprise a "phosphatidylglycerol lysyl transferase" (or synthetase) domain (DUF2156), also called "lysyl cardiolipid synthase" (Oku et al. 2004; Staubitz et al. 2004; Ernst et al. 2009). FmtC may be distantly related to lysyl-tRNA synthetases (TC# 9.B.111). Similar to 2.A.1.3.44 in all these respects. Ernst et al. 2015 and Slavetinsky et al. 2012 have reported that TMSs 1-6 of FmtC of S. aureus is a flippase for lysylinated phosphatidyl glycerol, and that the entire system is a dimer. | Bacteria |
Bacillota | FmtC of Staphylococcus aureus (D1QCY9) |
|
4.H.1.1.2 | Putative oxacillin resistance-associated protein, FmtC (872 aas; 14 N-terminal TMSs (residues 1-530) plus a largely hydrophilic DUF2156 domain (residues 531-872). Similar throughout its length to FmtC of Staphylococcus aureus (2.A.1.3.35). Residues 67-326 (TMSs 2-8) are homologous to residues 527-786 (TMSs 8-14) in Rv0585c of Mycobacterium tuberculosis (2.A.1.3.43). Residues 6-314 are also homologous to an extra hydrophobic domain in Mg2+ P-type ATPases (3.A.3.4.3 and 3.A.3.4.4). The C-terminal domain belongs to the DUF2156 superfamily. Homologues of the hydrophilic domain retrieved with NCBI BLAST searches are annotated as "putative" lysylphosphatidyl-glycerol synthetase. Some include full length MFS fusion proteins. | Bacteria |
Pseudomonadota | FmtC of Brucella melitensis (D1F3T8) |
|
4.H.1.1.3 | Putative MFS permease of 537 aas and 13 TMSs. TMSs 10-13 show substantial sequence similarity with TMSs 2-5 in 9.B.111.1.1 and 9.B.111.1.2). | Bacteria |
Thermodesulfobacteriota | Putative MFS permease of Bilophila wadsworthia (E5Y3Y1) |
|
4.H.1.1.4 | Bifunctional lysylphosphatidylglycerol flippase/synthetase of 850 aas and 15 TMSs in a 14 + 1 TMS arrangement, MprF. The structure of the C-terminal synthase domain has been determined (Hebecker et al. 2015). | Bacteria |
Bacillota | MprF of Bacillus licheniformis |
|
4.H.1.1.5 | Bifunctional alanyl phosphatidylglycerol flippase/synthetase MprF of 878 aas and 15 TMSs in a 14 + 1 TMS arrangement.The structure of the synthase domain has been determined (Hebecker et al. 2015). There may be a C-terminal TMS in addition to the 15 TMSs cited above. | Bacteria |
Pseudomonadota | MprF of Pseudomonas aeruginosa |
|
4.H.1.1.6 | Annotated as a putative lysyl tRNA synthetase with 7 putative N-terminal TMSs plus one putative C-terminal TMS. Pylogenetically, it clusters with the lysyl phosphatidyl glycerol synthases (ligases). | Bacteria |
Cyanobacteriota | Putative fusion protein of Anabaena variablis |
|
4.H.1.1.7 | DUF2156 domain-containing protein of 893 aas and 15 putative TMSs, 14 N-terminal and 1 C-terminal. The DUF2156 domain is the C-terminal hydrophilic domain. | Bacteria |
Actinomycetota | DUF2156 protein of Bifidobacterium pseudolongum |
|
4.H.1.1.8 | Uncharacterized protein of 867 aas and 14 putative TMSs. | Bacteria |
Bacillota | UP of Lactobacillus plantarum |
|
4.H.1.1.9 | Bifunctional lysylphosphatidylglycerol flippase/synthetase, MprF, of 848 aas and 14 TMSs in a 2 + 6 + 6 arrangement. | Bacteria |
Pseudomonadota | MprF of Hyphomonas adhaerens |
|
4.H.1.1.10 | Bifunctional lysylphosphatidylglycerol flippase/synthetase, MprF, of 850 aas and 15 or 16 putative TMSs in a 14 or 15 (N-terminal) +1 (C-terminal) TMS arrangement. | Bacteria |
Planctomycetota | MprF of Candidatus Brocadia sp. |
|
4.H.1.2.1 | Rv0585c; 795aas: 1 - 220aas, TMSs 1-6; 221-490aas, kinase domain; 491-795, TMS: 7-14. The C-terminal 8 TMS hydrophobic domain is homologous to an N-terminal domain in fused Mg2+-ATPases (3.A.3.4.3 and 3.A.3.4.4) and members of the MFS. | Bacteria |
Actinomycetota | Rv0585c of Mycobacterium tuberculosis (O53781) |
|
4.H.1.2.2 | Uncharacterized flippase-like domain-containing protein of 305 aas and 10 TMSs. | Bacteria |
Actinomycetota | UP of Streptomyces humi |
|
4.H.1.2.3 | Flippase-like domain-containing protein of 835 aas and 16 TMSs in a 6 + 6 + 4 TMS arrangement. | Bacteria |
Actinomycetota | Flippase of Jiangella alba |
|
4.H.1.2.4 | Uncharacterized protein of 1068 aas and 14 TMSs in a 6 + 5 + 3 TMS arrangment (UPF0104 family). . | Bacteria |
Bacillota | UP of Bacillus pumilus |