TCDB » SEARCH

TCID	Name	Domain	Kingdom/Phylum	Protein(s)
4.H.1.1.1	The 14 TMS FmtC (MprF: Multiple peptide resistance factor) protein of 840 aas, involved in methicillin and daptomycin resistance. Residues 1-550 comprise a 14TMS MFS permease domain while residues 551-840 comprise a "phosphatidylglycerol lysyl transferase" (or synthetase) domain (DUF2156), also called "lysyl cardiolipid synthase" (Oku et al. 2004; Staubitz et al. 2004; Ernst et al. 2009). FmtC may be distantly related to lysyl-tRNA synthetases (TC# 9.B.111). Similar to 2.A.1.3.44 in all these respects. Ernst et al. 2015 and Slavetinsky et al. 2012 have reported that TMSs 1-6 of FmtC of S. aureus is a flippase for lysylinated phosphatidyl glycerol, and that the entire system is a dimer.	Bacteria	Bacillota	FmtC of Staphylococcus aureus (D1QCY9)
4.H.1.1.2	Putative oxacillin resistance-associated protein, FmtC (872 aas; 14 N-terminal TMSs (residues 1-530) plus a largely hydrophilic DUF2156 domain (residues 531-872). Similar throughout its length to FmtC of Staphylococcus aureus (2.A.1.3.35). Residues 67-326 (TMSs 2-8) are homologous to residues 527-786 (TMSs 8-14) in Rv0585c of Mycobacterium tuberculosis (2.A.1.3.43). Residues 6-314 are also homologous to an extra hydrophobic domain in Mg²⁺ P-type ATPases (3.A.3.4.3 and 3.A.3.4.4). The C-terminal domain belongs to the DUF2156 superfamily. Homologues of the hydrophilic domain retrieved with NCBI BLAST searches are annotated as "putative" lysylphosphatidyl-glycerol synthetase. Some include full length MFS fusion proteins.	Bacteria	Pseudomonadota	FmtC of Brucella melitensis (D1F3T8)
4.H.1.1.3	Putative MFS permease of 537 aas and 13 TMSs. TMSs 10-13 show substantial sequence similarity with TMSs 2-5 in 9.B.111.1.1 and 9.B.111.1.2).	Bacteria	Thermodesulfobacteriota	Putative MFS permease of Bilophila wadsworthia (E5Y3Y1)
4.H.1.1.4	Bifunctional lysylphosphatidylglycerol flippase/synthetase of 850 aas and 15 TMSs in a 14 + 1 TMS arrangement, MprF. The structure of the C-terminal synthase domain has been determined (Hebecker et al. 2015).	Bacteria	Bacillota	MprF of Bacillus licheniformis
4.H.1.1.5	Bifunctional alanyl phosphatidylglycerol flippase/synthetase MprF of 878 aas and 15 TMSs in a 14 + 1 TMS arrangement.The structure of the synthase domain has been determined (Hebecker et al. 2015). There may be a C-terminal TMS in addition to the 15 TMSs cited above.	Bacteria	Pseudomonadota	MprF of Pseudomonas aeruginosa
4.H.1.1.6	Annotated as a putative lysyl tRNA synthetase with 7 putative N-terminal TMSs plus one putative C-terminal TMS. Pylogenetically, it clusters with the lysyl phosphatidyl glycerol synthases (ligases).	Bacteria	Cyanobacteriota	Putative fusion protein of Anabaena variablis
4.H.1.1.7	DUF2156 domain-containing protein of 893 aas and 15 putative TMSs, 14 N-terminal and 1 C-terminal. The DUF2156 domain is the C-terminal hydrophilic domain.	Bacteria	Actinomycetota	DUF2156 protein of Bifidobacterium pseudolongum
4.H.1.1.8	Uncharacterized protein of 867 aas and 14 putative TMSs.	Bacteria	Bacillota	UP of Lactobacillus plantarum
4.H.1.1.9	Bifunctional lysylphosphatidylglycerol flippase/synthetase, MprF, of 848 aas and 14 TMSs in a 2 + 6 + 6 arrangement.	Bacteria	Pseudomonadota	MprF of Hyphomonas adhaerens
4.H.1.1.10	Bifunctional lysylphosphatidylglycerol flippase/synthetase, MprF, of 850 aas and 15 or 16 putative TMSs in a 14 or 15 (N-terminal) +1 (C-terminal) TMS arrangement.	Bacteria	Planctomycetota	MprF of Candidatus Brocadia sp.
4.H.1.1.11	Lysyl tRNA synthetase of 601 aas and 7 or 8 putative TMSs in an apparent 6 + 1 TMS arrangement, possibly with an additional C-terminal TMS, LysS (shows sequence similarity to MFS permease-like proteins with TC#s 4.H.1 and 2.A.1.3.9).	Bacteria	Actinomycetota	LysSl of Streptomyces coelicolor (Q9X8H7)
4.H.1.1.12	Lysyl tRNA synthetase, LysS2 (shows extensive sequence similarity to MFS permease-like proteins with TC#s 4.H.1.1.	Bacteria	Actinomycetota	LysS2 of Streptomyces coelicolor (O69916)
4.H.1.1.13	DUF2156 domain-containing protein of 608 aas and 6 putative N-terminal TMSs, possibly followed by more, including one at the C-terminus.	Bacteria	Actinomycetota	DUF2156 protein of Kitasatospora cheerisanensis
4.H.1.1.14	DUF2156 domain-containing protein of 584 aas and 7 N-terminal TMSs.	Bacteria	Actinomycetota	DUF2156 of Frankia coriariae
4.H.1.1.15	Lysine-tRNA ligase of 909 aas and 6 central putatve TMSs (residues 401 to 560) with a C-terminal ligase domain. The transmembrane domain of this protein shows poor sequence similarity with other members of this family and with MFS porters.	Bacteria	Actinomycetota	tRNA ligase of Solirubrobacter pauli
4.H.1.2.1	Rv0585c; 795aas: 1 - 220aas, TMSs 1-6; 221-490aas, kinase domain; 491-795, TMS: 7-14. The C-terminal 8 TMS hydrophobic domain is homologous to an N-terminal domain in fused Mg²⁺-ATPases (3.A.3.4.3 and 3.A.3.4.4) and members of the MFS.	Bacteria	Actinomycetota	Rv0585c of Mycobacterium tuberculosis (O53781)
4.H.1.2.2	Uncharacterized flippase-like domain-containing protein of 305 aas and 10 TMSs.	Bacteria	Actinomycetota	UP of Streptomyces humi
4.H.1.2.3	Flippase-like domain-containing protein of 835 aas and 16 TMSs in a 6 + 6 + 4 TMS arrangement.	Bacteria	Actinomycetota	Flippase of Jiangella alba
4.H.1.2.4	Uncharacterized protein of 1068 aas and 14 TMSs in a 6 + 5 + 3 TMS arrangment (UPF0104 family). .	Bacteria	Bacillota	UP of Bacillus pumilus