TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
4.H.1.1.1









The 14 TMS FmtC (MprF: Multiple peptide resistance factor) protein of 840 aas, involved in methicillin and daptomycin resistance. Residues 1-550 comprise a 14TMS MFS permease domain while residues 551-840 comprise a "phosphatidylglycerol lysyl transferase" (or synthetase) domain (DUF2156), also called "lysyl cardiolipid synthase" (Oku et al. 2004; Staubitz et al. 2004; Ernst et al. 2009). FmtC may be distantly related to lysyl-tRNA synthetases (TC# 9.B.111). Similar to 2.A.1.3.44 in all these respects.  Ernst et al. 2015 and Slavetinsky et al. 2012 have reported that TMSs 1-6 of FmtC of S. aureus is a flippase for lysylinated phosphatidyl glycerol, and that the entire system is a dimer.

Bacteria
Firmicutes
FmtC of Staphylococcus aureus (D1QCY9)
4.H.1.1.2









Putative oxacillin resistance-associated protein, FmtC (872 aas; 14 N-terminal TMSs (residues 1-530) plus a largely hydrophilic DUF2156 domain (residues 531-872). Similar throughout its length to FmtC of Staphylococcus aureus (2.A.1.3.35). Residues 67-326 (TMSs 2-8) are homologous to residues 527-786 (TMSs 8-14) in Rv0585c of Mycobacterium tuberculosis (2.A.1.3.43). Residues 6-314 are also homologous  to an extra hydrophobic domain in Mg2+ P-type ATPases  (3.A.3.4.3 and 3.A.3.4.4). The C-terminal domain belongs to the DUF2156 superfamily. Homologues of the hydrophilic domain retrieved with NCBI BLAST searches are annotated as "putative" lysylphosphatidyl-glycerol synthetase. Some include full length MFS fusion proteins.

Bacteria
Proteobacteria
FmtC of Brucella melitensis (D1F3T8)
4.H.1.1.3









Putative MFS permease of 537 aas and 13 TMSs. TMSs 10-13 show substantial sequence similarity with TMSs 2-5 in 9.B.111.1.1 and 9.B.111.1.2).

Bacteria
Proteobacteria
Putative MFS permease of Bilophila wadsworthia (E5Y3Y1)
4.H.1.1.4









Bifunctional lysylphosphatidylglycerol flippase/synthetase of 850 aas and 15 TMSs in a 14 + 1 TMS arrangement, MprF.  The structure of the C-terminal synthase domain has been determined (Hebecker et al. 2015).

Bacteria
Firmicutes
MprF of Bacillus licheniformis
4.H.1.1.5









Bifunctional alanyl phosphatidylglycerol flippase/synthetase MprF of 878 aas and 15 TMSs in a 14 + 1 TMS arrangement.The structure of the synthase domain has been determined (Hebecker et al. 2015). There may be a C-terminal TMS in addition to the 15 TMSs cited above.

Bacteria
Proteobacteria
MprF of Pseudomonas aeruginosa
4.H.1.1.6









Annotated as a putative lysyl tRNA synthetase with 7 putative N-terminal TMSs plus one putative C-terminal TMS. Pylogenetically, it clusters with the lysyl phosphatidyl glycerol synthases (ligases).

Bacteria
Cyanobacteria
Putative fusion protein of Anabaena variablis
4.H.1.1.7









DUF2156 domain-containing protein of 893 aas and 15 putative TMSs, 14 N-terminal and 1 C-terminal. The DUF2156 domain is the C-terminal hydrophilic domain.

Bacteria
Actinobacteria
DUF2156 protein of Bifidobacterium pseudolongum
4.H.1.1.8









Uncharacterized protein of 867 aas and 14 putative TMSs.

Bacteria
Firmicutes
UP of Lactobacillus plantarum
4.H.1.1.9









Bifunctional lysylphosphatidylglycerol flippase/synthetase, MprF, of 848 aas and 14 TMSs in a 2 + 6 + 6 arrangement.

Bacteria
Proteobacteria
MprF of Hyphomonas adhaerens
4.H.1.1.10









Bifunctional lysylphosphatidylglycerol flippase/synthetase, MprF, of 850 aas and 15 or 16 putative TMSs in a 14 or 15 (N-terminal) +1 (C-terminal) TMS arrangement.

Bacteria
Planctomycetes
MprF of Candidatus Brocadia sp.
4.H.1.2.1









Rv0585c; 795aas: 1 - 220aas, TMSs 1-6; 221-490aas, kinase domain; 491-795, TMS: 7-14. The C-terminal 8 TMS hydrophobic domain is homologous to an N-terminal domain in fused Mg2+-ATPases (3.A.3.4.3 and 3.A.3.4.4) and members of the MFS.

Bacteria
Actinobacteria
Rv0585c of Mycobacterium tuberculosis (O53781)
4.H.1.2.2









Uncharacterized flippase-like domain-containing protein of 305 aas and 10 TMSs.

Bacteria
Actinobacteria
UP of Streptomyces humi
4.H.1.2.3









Flippase-like domain-containing protein of 835 aas and 16 TMSs in a 6 + 6 + 4 TMS arrangement.

Bacteria
Actinobacteria
Flippase of Jiangella alba
4.H.1.2.4









Uncharacterized protein of 1068 aas and 14 TMSs in a 6 + 5 + 3 TMS arrangment (UPF0104 family).

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Bacteria
Firmicutes
UP of Bacillus pumilus