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8.A.68.1.14
The Gm364 protein of 671 aas and 10 TMSs in a 1 + 1 + 2 + 2 + 2 + 2 TMS arrangement. Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation (Chen et al. 2021). Global knockout of Gm364 decreased the numbers of primordial follicles and growing follicles, impaired oocyte quality as indicated by increased ROS and gamma-H2AX, decreased mitochondrial membrane potential, decreased oocyte maturation, and increased aneuploidy. Mechanistically, Gm364 directly binds and anchors MIB2, a ubiquitin ligase, on the membrane. Subsequently, membrane MIB2 ubiquitinates and activates DLL3. Next, the activated DLL3 binds and activates Notch2, which is subsequently cleaved within the cytoplasm to produce NICD2, the intracellular active domain of Notch2. Finally, NICD2 can directly activate AKT within the cytoplasm to regulate oocyte meiosis and quality (Chen et al. 2021).

Accession Number:NP_001122097.1
Protein Name:NP_001122097.1 uncharacterized protein LOC245423 [Mus musculus]
Length:672
Molecular Weight:
Species:Mus musculus [10090]
Number of TMSs:10
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVVPEAGFKM GLSGRRVETK LCPGLHGLKW WLLLCFLATT CDAFFFPGLV PVTYCEEGHP 
61:	NSYCKSSIQV YADKLYSVDS VMFYDYDSFD FCQDSLKRTP SETLGQILFG EQVTSCPYKF 
121:	SFNKDETCRK VCVKSYAPDN EDDMNKLAFL KKGIKQDYRH HWIVDNTGII WCYDTENEEH 
181:	HCMSGFPIGC FNAPSDQVKG SCLINPEFNK NNSLYLFNHL DITITYHIES DTTVKVAKLI 
241:	SSRVDPKSYK HLDEDHLTCN EPPMEIPEED TENLNVIYTY SVKFEESKAT EWSSEGDYDL 
301:	DSTAETSLQW IRLVNSFFVV LFLCGLVVIL LLRSIWRDIA KFNRIKISVY DRRLFGWRLI 
361:	HGNLFRLPEH GMLLSILLGQ GTQVFIMTFL SLFLAGLGFL TPADQNVLVN YGVVLWLALE 
421:	IPAGYMSAKM YKTFKGINWK MHFLLTTVLF PGIVFADIFI MNLILWMDGS PAAISFCTLA 
481:	SLFALYFGVS TPLTFLGVYF GKREKFEFPV YAPKHEHGSP QRTFFPKSTI TIILGSLLPF 
541:	GCIFLQLSYI LNRIWSPHMY YLFAFLLLLF LIFMISCSEV TVLLCYFRLC AEDRGWWWRA 
601:	FLTSSFTSAY IFIYVIHYFF TKLQVTSIGS TFMYFGYAFI LVLAFFLFTG TIGFFSCFFF 
661:	VTTIYGVIKE D