9.A.14.10.5
G-protein coupled receptor, NPSR1, for neuropeptide S (NPS) and promotes mobilization of intracellular Ca2+ stores (Bernier et al. 2006). It also inhibits cell growth in response to NPS binding (Vendelin et al. 2005). It is involved in the pathogenesis of asthma and other IgE-mediated diseases (Xu et al. 2004; Bernier et al. 2006).
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| Accession Number: | Q6W5P4 |
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| Protein Name: | Neuropeptide S receptor |
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| Length: | 371 |
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| Molecular Weight: | 42687.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF
61: VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDSFTGLV NILTDINWRF TGDFTAPDLV
121: CRVVRYLQVV LLYASTYVLV SLSIDRYHAI VYPMKFLQGE KQARVLIVIA WSLSFLFSIP
181: TLIIFGKRTL SNGEVQCWAL WPDDSYWTPY MTIVAFLVYF IPLTIISIMY GIVIRTIWIK
241: SKTYETVISN CSDGKLCSSY NRGLISKAKI KAIKYSIIII LAFICCWSPY FLFDILDNFN
301: LLPDTQERFY ASVIIQNLPA LNSAINPLIY CVFSSSISFP CREQRSQDSR MTFRERTERH
361: EMQILSKPEF I