TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.105.1.1









PbrB/C fusion protein of 358 aas and 10 - 12 TMSs. Confers resistance to Pb2+ (Taghavi et al., 2009).  May be a phosphatase. While PbrA non-specifically exported Pb2+, Zn2+ and Cd2+, a specific increase in lead resistance is observed when PbrA and PbrB are coexpressed. Possibly Pb2+ is exported from the cytoplasm by PbrA and then sequestered as a phosphate salt with the inorganic phosphate produced by PbrB. Similar operons containing genes for heavy metal translocating ATPases and phosphatases can be found in many different bacterial species, suggesting that lead detoxification through active efflux and sequestration is a common lead-resistance mechanism (Hynninen et al. 2009).

Bacteria
Proteobacteria
PbrB/C fusion protein of Ralstonia (Cupriavidus) metallidurans (Q58AJ7)
9.B.105.1.2









Hypothetical protein, HEAR1543. Residues 1-200 45% identity to PbrB which has 312 aas with 6 TMSs. The c-terminal domain contains a DUF3703 domain.

Bacteria
Proteobacteria
HEAR1543 of Herminiimonas arsenicoxydans (A4G5C1)
9.B.105.1.3









Undecaprenyl-diphosphatase BcrC (EC 3.6.1.27) (Undecaprenyl pyrophosphate phosphatase)
Bacteria
Firmicutes
bcrC of Bacillus subtilis
9.B.105.1.4









Hypothetical protein

Bacteria
Planctomycetes
HP of Rhodopirellula baltica
9.B.105.1.5









Lipoprotein signal peptidase of the Peptidase A8 Superfamily; IspA: geranyltranstransferase (Farnesyl-diphosphate synthase).

Bacteria
Firmicutes
Peptidase of Clostridium cellulolyticum
9.B.105.1.6









Putative phosphatase of 178 aas and 4 TMSs.

Bacteria
Spirochaetes
Putative phosphatase of Leptospira interrogans
9.B.105.1.7









Uncharacterized protein of 188 aas and 5 or 6 TMSs

Bacteria
Proteobacteria
UP of Bdellovibrio bacteriovorus
9.B.105.1.8









Lipoprotein signal peptidase of 310 aas and 6 TMSs, IspA. 

Bacteria
Proteobacteria
IspA of Bdellovibrio bacteriovorus
9.B.105.1.9









Uncharacterized protein of 141 aas and 4 TMSs (Hug et al. 2016).

Bacteria
Candidatus Peregrinibacteria
UP of Candidatus Peribacter riflensis
9.B.105.1.10









Plasma-membrane-bound acidic pyrophosphatase (exo-PPase) of 206 aas and 5 TMSs. It represents proteins with the conserved phosphatase motif KxxxxxRP-(x12-54)-PSGH-(x31-54)-SRxxxxxHxxxD. Phosphatase or pyrophosphatase activity was described for the Sulfolobus acidocaldarius protein. It may function in resistance to the peptide antibiotic bacitracin (Moll and Schäfer 2004).

Archaea
Crenarchaeota
ExoPPase of Sulfolobus acidocaldarius
9.B.105.2.1









Putative phosphatase of 321 aas and 9 TMSs

Bacteria
Spirochaetes
Putative phosphatase of Leptospira interrogans
9.B.105.2.2









Membrane-associated phospholipid phosphatase of 223 aas and 6 TMSs.

Bacteria
Firmicutes
Phosphatase of Lactobacillus paracasei
9.B.105.2.3









YodM (PgpB), the principal phosphatidylglycerol phosphate (PGP) phosphatase of 203 aas and 5 or 6 TMSs in B. subtilis. The crystal structure is known (Ghachi et al. 2017).
Bacteria
Firmicutes
PgpB of Bacillus subtilis
9.B.105.2.4









Phosphatase PAP2 family proteinof 237 aas and 6 TMSs.

Bacteria
Proteobacteria
PAP2 family protein of Maritimibacter alkaliphilus
9.B.105.3.1









Putative phosphatidate phosphatase of 412 aas and 8 TMSs, Ppp

Eukaryota
Metazoa
Ppp of Lucilia cuprina
9.B.105.3.2









Diacylglycerol pyrophosphate (DGPP) phosphatase catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). It regulates intracellular DGPP and PA levels, which play a signaling role in stress responses. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. Substrate preference is DGPP > LPA > PA. Activity is independent of a divalent cation ion (Wu et al. 1996).  The protein probably has 6 TMSs with two 3-TMS repeats.

Eukaryota
Fungi
DGPP phosphatase of Saccharomyces cerevisiae (Baker's yeast)
9.B.105.3.3









Putative phosphatase of 223 aas and 5 TMSs.

Bacteria
Proteobacteria
Putative phosphatase of Bdellovibrio exovorus
9.B.105.3.4









Putative phospholipid phosphatase of 326 aas and 8 TMSs

Bacteria
Firmicutes
PL phosphatase of Lactobacillus rhamnosis
9.B.105.4.1









Uncharacterized protein of 217 aas and 8 TMSs in a 2 + 2 + 2 + 2 arrangement.

Bacteria
Firmicutes
UP of Desulfitobacterium hafniense
9.B.105.4.2









Uncharacterized protein of 201 aas and 6 TMSs.  Annotated as a phosphoesterase PA-phosphatase-like protein of the PAP2 superfamily.

Archaea
Euryarchaeota
PAP2 protein of Methanobacterium formicicum
9.B.105.4.3









Uncharacterized protein of 206 aas and 6 TMSs.  Shows some sequence similarity with 9.A.29.3.2 (e-valute of 0.0008 over 118 aas).

Bacteria
Actinobacteria
UP of Streptomyces sulphureus
9.B.105.4.4









Putative uncharacterized phosphatase of 191 aas and 6 TMSs.

Bacteria
Candidatus Beckwithbacteria
PAP2 family protein of Candidatus Beckwithbacteria bacterium
9.B.105.4.5









Putative phosphatase PAP2 family protein of 193 aas and 6 TMSs.

Bacteria
Actinobacteria
PAP2 family protein of Micromonospora wenchangensis
9.B.105.4.6









Uncharacterized protein of 230 aas and 6 putative TMSs

Bacteria
Bacteroidetes
UP of Chitinophaga sp.
9.B.105.4.7









Phosphatase PAP2 family protein of 197 aas and 6 TMSs.

Bacteria
Actinobacteria
PAP2 family protein of Rathayibacter sp.
9.B.105.5.1









PAP2 family phosphodiesterase of 239 aas and 5 TMSs.

Bacteria
Proteobacteria
PAP2 protein of Bdellovibrio exovorus
9.B.105.5.2









Putative phosphodiesterase of 323 aas and 4 - 6 TMSs.

Bacteria
Bacteroidetes
Phosphodiesterase of Bacteroides ovatu
9.B.105.5.3









Phosphoesterase PA-phosphatase related protein of 234 aas and 6 probable TM

Bacteria
Gemmatimonadetes
Phosphatase of Gemmatirosa kalamazoonesis
9.B.105.6.1









Uncharacterised protein of 308 aas and 8 TMSs

Bacteria
Actinobacteria
UP of Dermatophilus congolensis
9.B.105.6.2









Phosphatase PAP2 family protein of 357 aas and 8 TMSs.

Bacteria
Actinobacteria
PAP2 family protein of Bombiscardovia coagulans
9.B.105.6.3









Uncharacterized protein of 388 aas and 8 TMSs in a 1 + 5 + 2 arrangement.

Bacteria
Actinobacteria
UP of Tetrasphaera japonica