| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.C.74.1.1 | Cobra cardiotoxin-1 (cytotoxin CM-6), CTX1. It is a basic protein that binds to cell membranes and depolarizes cardiomyocytes. It also possesses lytic activity on many cells, including red blood cells (Chien et al. 1994). Cytotoxicity is due to pore formation and to another mechanism independent of membrane-damaging activity (Wang et al. 2006). | Eukaryota |
Metazoa, Chordata | CTX1 of Naja naja (P60305) |
|
1.C.74.1.2 | α-bungarotoxin isoform A31 (α-BTX A31) (blocks activity of the nicotinic acetylcholine receptor (TC #1.A.9) | Eukaryota |
Metazoa, Chordata | αBTX A31 of Bungarus multicinctus (P60615) |
|
1.C.74.1.3 | β-cardiotoxin, CTX14, of 84 aas. | Eukaryota |
Metazoa, Chordata | CTX14 pf Ophiophagus hannah (King cobra) (Naja hannah) |
|
1.C.74.1.4 | Long neurotoxin 43, LNTX43 of 108 aa | Eukaryota |
Metazoa, Chordata | LNTX-43 of Drysdalia coronoides (White-lipped snake) (Hoplocephalus coronoides) |
|
1.C.74.1.5 | Bucain of 65 aas | Eukaryota |
Metazoa, Chordata | Bucain of Bungarus candidus (Malayan krait) |
|
1.C.74.1.6 | 3 finger muscarinic toxin, Mt1 of 66 aas. Shows a non-competitive interaction with adrenergic and muscarinic receptors. Binds to alpha-2b (ADRA2B) (IC50=2.3 nM), alpha-1a (ADRA1A), alpha-1b (ADRA1B), and alpha-2c (ADRA2C) adrenergic receptors. Reversibly binds to M1 (CHRM1) muscarinic acetylcholine receptors, probably by interacting with the orthosteric site. | Eukaryota |
Metazoa, Chordata | MT1 of Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps) |
|
1.C.74.1.7 | α-elapitoxin 2a, Nno2a of 73 aas | Eukaryota |
Metazoa, Chordata | Nno2a of Naja oxiana (Central Asian cobra) (Oxus cobra) |
|
1.C.74.1.8 | Muscarinic toxin MT7 of 88 aas and 1 TMS. Forms a complex with the M1 muscarinic receptor with subnanomorlar affinity with a very slow dissociation rate. The 3-D crystal structure is known and reveals how it inhibits agonist-mediated GTP-γ-S binding and downstream signaling (Maeda et al. 2020). | Eukaryota |
Metazoa, Chordata | MT7 of Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps) |
|
1.C.74.1.9 | Cytotoxin 1f of 15 aas. It shows cytolytic activity on many different cells by forming a pore in lipid membranes. In vivo, it increases heart rate or kills the animal by cardiac arrest. In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity. | Eukaryota |
Metazoa, Chordata | Cytotoxin 1f of Naja atro (Chinese cobra) |